At least two people were reportedly killed by a train derailment that sent about 12 cars filled with coal toppling off the tracks at around 11:45 p.m., according to sources.
The freight train, headed towards Catonsville, derailed near the on Mulligan Hill Lane.
Main Street is closed from Old Columbia Pike in Howard County to Oella Avenue in Baltimore County.
Rescue crews from Howard and Baltimore Counties are responding to the scene.
Fire department sources said that two people who were on the bridge at the time were killed.
Check back with Patch as this story develops.